Conference Day One | Wednesday, July 24 2024
8:00 am Check-In & Networking
8:45 am Chair’s Opening Remarks & Welcome
Accelerated Tech Innovation & Optimization of Constrained Peptide Characterization for Enhanced Efficiency & Cost Effectiveness
9:00 am Energizing Discussion: Where Have We Been, Where Are We Now & Where Are We Going?
Synopsis
Your chance to dive in with your peers through the dynamic evolution of peptide science. From traditional synthesis and purification methods that laid the foundation for the remarkable progress made thus far, and the cutting-edge development propelling us forward. Together, we’ll delve into the future landscape and what that looks like in this rapidly evolving field.
9:30 am Better Medicines, Created Rapidly through De Novo Protein Design
Synopsis
- Integrating artificial intelligence, synthetic biology, and robotics to expedite the discovery and optimization of protein binders, generating a diverse array of modular miniprotein domains characterized by optimal drug-like properties and developability profiles
- Showcasing the distinct attributes of miniproteins by pioneering first-in-class NK cell engagers for oncology, along with leading therapeutics targeting TNFR1 for inflammation and GLP1R for metabolic disease
- Utilizing advanced technologies to create a vast toolbox of miniprotein domains, demonstrating their potential in addressing various medical challenges and advancing therapeutic innovation
10:00 am Speed Networking & Morning Coffee
Synopsis
Join us for an exhilarating session of speed networking to kick-start the conference. Connect with industry peers, exchange insights, and forge valuable partnerships in just minutes, accelerating your professional network in the dynamic world peptide process development.
11:00 am Engineering Peptides at the Speed of Light
Synopsis
- Showcasing high complexity peptide library synthesis on solid support with proprietary Nimble technology
- Focusing on quality control of synthesized peptides on array
- Uncovering lead candidate optimization using Nimble technology: a case study
11:30 am Optimizing Peptide-Antibody Conjugates: Synthesis, Characterization & Tuning
Synopsis
- Exploring novel chemical methods to link peptides targeting GPCRs to antibodies
- Examining the tunability of properties in the resulting peptide-antibody conjugates for potential translational applications
- Highlighting the advantages and challenges of the semi-synthetic approach in optimizing the synthesis and characterization of these conjugates
12:00 pm Continuous Monitoring of Solid-Phase with Refractive Index Tools for Accelerated Peptide Development
Synopsis
- Utilizing innovative refractive index tools for real-time monitoring of solid-phase therapeutic synthesis, reducing time and enhancing process efficiency
- Departing from traditional time-consuming and impractical post-synthesis analysis, this pioneered method allows continuous monitoring within the solid-phase reactor, providing insight without disrupting the process
- While focused on peptide synthesis, this approach’s applicability extends to oligonucleotide synthesis, showcasing the power and potential across diverse molecular domains
12:30 pm Lunch & Networking
Exploring Novel Approaches for Enhanced Peptide Synthesis Efficiency & Green Chemistry
1:30 pm Spotlight & Discussion: Advancements & Challenges in Solid Phase Synthesis of Difficult Peptides
Synopsis
- Integrating advanced resin and linker technologies to improve peptide solubility during synthesis
- Utilization solubilizing agents and auxiliary additives to facilitate dissolution and processing of hydrophobic peptide sequences
- Incorporating solubility-enhancing modifications and structural motifs into peptide design to improve overall solubility profile
2:00 pm Synthesis of Cys Containing Peptides
Synopsis
- Cys is the most versatile amino acid involved in many reactions
- The thiol of Cys can be masked with different protecting groups to fulfil all Cys applications
- At the same time, Cys can suffer a large number of side-reactions
2:30 pm Panel Discussion: Revolutionizing Peptide Production – Alternatives to SPPS
Synopsis
- Investigating solution-phase peptide synthesis methodologies, including liquid-phase, batch, and fragment condensation approaches, for the synthesis of complex peptide sequences
- Optimizing reaction conditions and purification strategies to achieve high yields and purity in solution-phase and non-SPPS peptide synthesis methods
- Integrating hybrid synthetic approaches combining elements of SPPS with alternative synthesis methods to capitalize on the strengths of each approach and overcome inherent limitations
3:15 pm Break & Networking
3:45 pm Continuous-Flow Solid-Phase Peptide Synthesis to Enable Rapid, Multi- Gram Deliveries of Peptides
Synopsis
- Peptides are emerging as a powerful modality within pharmaceutical development capable of treating a wide variety of diseases
- Traditionally, peptides are constructed via solid-phase peptide synthesis (SPPS) in a batch process which is notorious for using excess reagents and generating large amounts of reprotoxic solvent waste such as DMF
- CF-SPPS offers a data-rich and rapid approach to optimize peptide syntheses on small scale with line of sight to large scale preparation of peptides while harnessing significant reductions in time and waste compared to batch-operated SPPS
4:15 pm Novel Methodology for Forming Amide Bonds Using Mechanochemistry in Flow
Synopsis
- Mechanochemistry in flow for amide bond formation in peptides
- Optimizing methodology reduces solvent use and waste generation
- Advancing peptide synthesis while aligning with green chemistry principles